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AU2022409850A1 — Computer-based systems for acquiring and analyzing observational subject data

Assignee: PGI Drug Discovery LLC · Inventors: Hasan Almawi, Alberto Ambesi-Impiombato, Mukesh Bansal, Daniela Brunner, and others Filed: 2022-12-16 (PCT/US2022/053289) · Status: Ceased

Abstract

Devices, systems, and methods for capturing and analyzing behavioral and physiological data of subjects for treatment, modification, and manipulation discovery. An instrumented enclosure with sensing devices captures observational data from an animal subject administered a drug. Machine-learning feature extraction + classifier predicts drug class labels from behavioral features. Used for drug screening and phenotypic treatment discovery.

Key technical features

  • Brain recording: YES — 152 EEG mentions; 23 “electrode”; 50 “neural”; pEEG (pharmacological EEG) is a core modality; rodent pEEG translates to receptor affinity prediction
  • Species: Animal (rodent) — 348 “animal”; 111 “rodent”; 54 “mouse”; 13 “rat”; 469 “subject”; 24 “human” (translational context)
  • Classification: G16H70/40 (drug side effects/usage); G16H20/10 (drug administration monitoring); A61B5/4848 (treatment effects monitoring); G06V10/40 (image feature extraction); G06V40/10 (animal body recognition)
  • ML pipeline: Feature extraction (instant behavioral features) → higher-order features (state extraction, motif extraction, domain features) → supervised/unsupervised ML classifier → drug class label prediction
  • Sensor modalities: Camera (141 mentions), depth (11), EEG (152), video (138), sensor (267)
  • Behavioral features: forward walk, immobile, turn around, backward walk; state features, motif features, domain features

Significance

This is the most relevant patent found for “automated cognitive training systems for research animals” — it is a comprehensive rodent drug-screening platform that combines behavioural monitoring (camera/video in instrumented enclosure) with pharmacological EEG (pEEG) and machine-learning-based drug classification. PGI Drug Discovery (PsychoGenics/Innovive partnership) uses this for phenotypic drug discovery — administering compounds to rodents, capturing behavioural + EEG data, and classifying drug effects via ML. The pEEG dimension makes it the first patent in this collection with both rodent subjects AND brain recording as a core modality. Ceased (not granted in AU), but the PCT family may be active in other jurisdictions.

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